Voltammetric Determination of Paracetamol with Poly (3, 4-Ethylenedioxythiophene) PEDOT modified Glassy Carbon Electrode

Abstract

The voltammetric oxidation of paracetamol on poly (3, 4-Ethylenedioxythiophene) PEDOT modified glassy carbon electrode was explored in 0.1M sodium acetate buffer solution by using cyclic and differential pulse viltammetry. Cyclic and differential pulse voltammetry studies indicated that oxidation of paracetamol at the electrode surface as a two-electron reversible step and fundamentally controlled by diffusion. A quasi-reversible redox process of paracetamol at modified electrode was obtained and the over-potential of paracetamol decreased significantly compared with that at bare electrode. PEDOT modified electrode showed excellent performance for detecting paracetamol in the linear detection range between 9.99 x 10-6 to 3.38 x 10-4 M, with a detection limit of 4.7 x 10-6 M and a sensitivity of 0.043 A/M. The method was then successfully utilised for the determination of paracetamol in a real samples of Panado tablets and Ibupain capsule with recoveries of 99.1% and 80.7% respectively for each sample.